Clinical Trials
University of Florida neurologists and neurosurgeons serve as primary investigators in Phase II-IV clinical research studies that will someday determine the most accurate outcomes available in neurological disease treatment. Many of these clinical research trials are granted to just a few specialists and hospitals throughout the nation or the world.
A patient who meets guidelines outlined in a study protocol can participate in a clinical trial. Neuroscience physicians and their research teams provide participating patients with details of the study and regularly monitor and record their progress.
For more information about patient participation in the Neuroscience Institute Clinical Research Program, call (904) 244-9856 .
The Neuroscience Institute is enrolled in the following research trials:
Clinical Trials
A 24-month double-blind, randomized, multicenter, placebo-controlled, parallel-group study comparing the efficacy and safety of 0.5mg and 1.25mg fingolimod (FTY720) administered orally once daily versus placebo in patients with relapsing -remitting multiple sclerosis Protocol No. CFTY720D2309 Keywords: MS, multiple sclerosis A 6-month, Randomized, Active Comparator, Open-label, Multi-Center Study to Evaluate Patient Outcomes, Safety and Tolerability of Fingolimod (FTY720) 0.5mg/day in Patients with Relapsing Remitting Multiple Sclerosis who are candidates for MS therapy change from Previous Disease Modifying Therapy (EPOC) Keywords: Multiple Sclerosis, MS A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects with a History of Atherosclerotic Disease: Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 P – TIMI 50) P04737 Keywords: Heart Disease, Atherosclerotic Disease, atherothrombotic Ischemic Events A Phase 3, Multicenter, Double-blind, Placebo-controlled Randomized Discontinuation Study Followed by an Open-label Extension Period to Evaluate the Efficacy and Safety of Amifampridine Phosphate (3,4-Diaminopyridine Phosphate) in Patients with Lambert-Eaton Myasthenic Syndrome (LEMS) (LMS-002) Keywords: Lambert-Eaton Myasthenic Syndrome, LEMS A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Stroke. ALIAS Keywords: Acute Ischemic Stroke A Prospective, Randomized, Double Blinded Trial of the Efficacy of a “Skin-CNS-Bladder” Reinnervation Procedure in Patients Undergoing Spinal Cord Untethering Procedures Keywords: Bladder Disorder, Neurogenic Bladder, Spina Bifida A Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Multi-Center Study of Eculizumab in Patients with Generalized Myasthenia Gravis (gMG) who have Moderate to Severe Muscle Weakness Despite Treatment with Immunosuppressants Keywords: Neuromuscular Disorderm Generalized Myasthenia Gravis, GMG, Eculizamub, Muscle Weakness A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Trial Of Pregabalin CR As Adjuntive Therapy In Adult Patients With Partial Onset Seizures Keywords: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study to Evaluate the Efficacy and Safety of USL255 as Adjunctive Therapy in Patients with Refractory Partial-Onset Seizures (P09-004) Keywords: Neurological Disorder, Epilepsy, Seizures An Extension Protocol for Multiple Sclerosis Patients Who Participated in Genzyme-Sponsored Studies of Alemtuzumab (CAMMS03409) Keywords: Multiple Sclerosis, relapsing-remitting MS, MS Cervical Dystonia - Patient Registry for Observation of BOTOX Efficacy (CD-PROBE) Keywords: cervical dystonia, spasmodic torticollis Comparison of the Epidemiology and Characteristics of Asthma and COPD Exacerbations in Patients with Recreational Drug Use Keywords: COPD, Asthma, Cocaine, Marijuana Controlled Trial of 3, 4 Diaminopyridine in Lambert-Eaton Myastenic Syndrome (LEMS) Keywords: Neuromuscular Disorder, Lambert-Eaton Myastenic Syndrome, LEMS Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures in a Doubel-Blind, Randomised, Placebo-Controlled, Parallel-Group, Multicentre Clinical Trial Keywords: Genetic Risk Factors for Medication-Related Hemorrhagic Stroke Keywords: Intracerebral Hemorrhage (ICH), Bleeding; brain; thinning of blood Healthcare Disparities In Cancer Presentation And Outcomes Keywords: Cancer, Emergency Room use, Health Services Research IRIS - Insulin Resistance Intervention After Stroke Trial Keywords: Stroke; TIA, Insulin Resistance JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri®: STRATIFY-2 (101JC402) Keywords: Central Nervous System Disease, Multiple Sclerosis, MS Late Development of epileptiform Activity on Electroencephalography in Cerebral Cortical Infarction Keywords: Stroke, EEG Long-Term Eslicarbazepine Acetate Extension Study (Protocol 093-050) Keywords: Epilepsy, seizures Open-Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel In Subjects With Advanced Parkinson's Disease And Severe Motor-Fluctuations Who Have Exhibited A Persistent and Positive Effect To Treatment In Previous Studies Keywords: Advanced Parkinson's Disease Open-Label Extension Study to Evaluate the Safety of USL255 as Adjunctive Therapy in Patients with Refractroy Partial-0nset Seizres who had Participated in P09-004, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study (P09-005) Keywords: Neurological Disorder, Epilepsy, Seizure Open-Label, 12-Month Safety and Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Disease Subjects (S187.3.003) Keywords: Idiopathic Parkinson's Disease, PD Open-Label, 6-12 Months Safety and Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Subjects with Advanced Parkinson's Disease and Severe Motor-Fluctuations (S187.3.004) Keywords: Parkinson’s Disease, Levodopa-Carbidopa Intestinal Gel Outcomes of cocaine induced intra-parenchymal hemorrhages Keywords: Brain bleed, cocaine induced intra-parenchymal hemorrhages Platelet-Oriented Inhibition in New TIA and minor ishemic stroke (POINT) Trial, a Randomized, Double-Blind, Multicenter Clinical Trial Keywords: Transient Ischemic Attack, TIA, Ischemic Stroke Post Stroke Nursing Assessment Tool (PSAT) Keywords: Stroke, NIHSS, Nursing Assessment RT2CR: A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma and Observation for Craniopharyngioma after Radical Resection Keywords: Craniopharyngioma, proton radiation, pediatric Spot Sign for Predicting and Treating ICH Growth Study (STOP-IT Study) Keywords: Acute spontaneous Intracerebral Hemorrhage, Teaching Public Health to Residents and Medical Students Using a Self-Directed Learning Module on Obesity Keywords: Public Health, obesity, medical trainees The Prevalence of Obstructive Sleep Apnea in Patients with Idiopathic Intracranial Hypertension Keywords: Prevalence, obstructive Sleep Apnea, Idiopathic Intracranial Hypertension Thymectomy in non-thymomatous MG patients receiving prednisone therapy Keywords: Neuromuscular Disorder, Thymectomy; prednisone, Myasthenia Gravis
All Research
A 24-month double-blind, randomized, multicenter, placebo-controlled, parallel-group study comparing the efficacy and safety of 0.5mg and 1.25mg fingolimod (FTY720) administered orally once daily versus placebo in patients with relapsing -remitting multiple sclerosis Protocol No. CFTY720D2309 Keywords: MS, multiple sclerosis A 6-month, Randomized, Active Comparator, Open-label, Multi-Center Study to Evaluate Patient Outcomes, Safety and Tolerability of Fingolimod (FTY720) 0.5mg/day in Patients with Relapsing Remitting Multiple Sclerosis who are candidates for MS therapy change from Previous Disease Modifying Therapy (EPOC) Keywords: Multiple Sclerosis, MS A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of SCH 530348 in Addition to Standard of Care in Subjects with a History of Atherosclerotic Disease: Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events (TRA 2 P – TIMI 50) P04737 Keywords: Heart Disease, Atherosclerotic Disease, atherothrombotic Ischemic Events A Phase 3, Multicenter, Double-blind, Placebo-controlled Randomized Discontinuation Study Followed by an Open-label Extension Period to Evaluate the Efficacy and Safety of Amifampridine Phosphate (3,4-Diaminopyridine Phosphate) in Patients with Lambert-Eaton Myasthenic Syndrome (LEMS) (LMS-002) Keywords: Lambert-Eaton Myasthenic Syndrome, LEMS A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Stroke. ALIAS Keywords: Acute Ischemic Stroke A Prospective, Randomized, Double Blinded Trial of the Efficacy of a “Skin-CNS-Bladder” Reinnervation Procedure in Patients Undergoing Spinal Cord Untethering Procedures Keywords: Bladder Disorder, Neurogenic Bladder, Spina Bifida A Randomized, Double-Blind, Placebo-Controlled, Cross-Over, Multi-Center Study of Eculizumab in Patients with Generalized Myasthenia Gravis (gMG) who have Moderate to Severe Muscle Weakness Despite Treatment with Immunosuppressants Keywords: Neuromuscular Disorderm Generalized Myasthenia Gravis, GMG, Eculizamub, Muscle Weakness A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Trial Of Pregabalin CR As Adjuntive Therapy In Adult Patients With Partial Onset Seizures Keywords: A Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study to Evaluate the Efficacy and Safety of USL255 as Adjunctive Therapy in Patients with Refractory Partial-Onset Seizures (P09-004) Keywords: Neurological Disorder, Epilepsy, Seizures An Extension Protocol for Multiple Sclerosis Patients Who Participated in Genzyme-Sponsored Studies of Alemtuzumab (CAMMS03409) Keywords: Multiple Sclerosis, relapsing-remitting MS, MS Cervical Dystonia - Patient Registry for Observation of BOTOX Efficacy (CD-PROBE) Keywords: cervical dystonia, spasmodic torticollis Comparison of the Epidemiology and Characteristics of Asthma and COPD Exacerbations in Patients with Recreational Drug Use Keywords: COPD, Asthma, Cocaine, Marijuana Controlled Trial of 3, 4 Diaminopyridine in Lambert-Eaton Myastenic Syndrome (LEMS) Keywords: Neuromuscular Disorder, Lambert-Eaton Myastenic Syndrome, LEMS Efficacy and Safety of Eslicarbazepine Acetate (BIA 2-093) as Adjunctive Therapy for Refractory Partial Seizures in a Doubel-Blind, Randomised, Placebo-Controlled, Parallel-Group, Multicentre Clinical Trial Keywords: Genetic Risk Factors for Medication-Related Hemorrhagic Stroke Keywords: Intracerebral Hemorrhage (ICH), Bleeding; brain; thinning of blood Healthcare Disparities In Cancer Presentation And Outcomes Keywords: Cancer, Emergency Room use, Health Services Research IRIS - Insulin Resistance Intervention After Stroke Trial Keywords: Stroke; TIA, Insulin Resistance JCV Antibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri®: STRATIFY-2 (101JC402) Keywords: Central Nervous System Disease, Multiple Sclerosis, MS Late Development of epileptiform Activity on Electroencephalography in Cerebral Cortical Infarction Keywords: Stroke, EEG Long-Term Eslicarbazepine Acetate Extension Study (Protocol 093-050) Keywords: Epilepsy, seizures Open-Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel In Subjects With Advanced Parkinson's Disease And Severe Motor-Fluctuations Who Have Exhibited A Persistent and Positive Effect To Treatment In Previous Studies Keywords: Advanced Parkinson's Disease Open-Label Extension Study to Evaluate the Safety of USL255 as Adjunctive Therapy in Patients with Refractroy Partial-0nset Seizres who had Participated in P09-004, a Randomized, Multicenter, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 3 Study (P09-005) Keywords: Neurological Disorder, Epilepsy, Seizure Open-Label, 12-Month Safety and Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Parkinson's Disease Subjects (S187.3.003) Keywords: Idiopathic Parkinson's Disease, PD Open-Label, 6-12 Months Safety and Efficacy Study of Levodopa-Carbidopa Intestinal Gel in Levodopa-Responsive Subjects with Advanced Parkinson's Disease and Severe Motor-Fluctuations (S187.3.004) Keywords: Parkinson’s Disease, Levodopa-Carbidopa Intestinal Gel Outcomes of cocaine induced intra-parenchymal hemorrhages Keywords: Brain bleed, cocaine induced intra-parenchymal hemorrhages Platelet-Oriented Inhibition in New TIA and minor ishemic stroke (POINT) Trial, a Randomized, Double-Blind, Multicenter Clinical Trial Keywords: Transient Ischemic Attack, TIA, Ischemic Stroke Post Stroke Nursing Assessment Tool (PSAT) Keywords: Stroke, NIHSS, Nursing Assessment RT2CR: A Phase II Trial of Limited Surgery and Proton Therapy for Craniopharyngioma and Observation for Craniopharyngioma after Radical Resection Keywords: Craniopharyngioma, proton radiation, pediatric Spot Sign for Predicting and Treating ICH Growth Study (STOP-IT Study) Keywords: Acute spontaneous Intracerebral Hemorrhage, Suitability of Endoscopic Endonasal Approach to Patients with Basilar Invagination: A Radiologic Study Keywords: Basilar invagination, endoscopy, skull base, radiology Teaching Public Health to Residents and Medical Students Using a Self-Directed Learning Module on Obesity Keywords: Public Health, obesity, medical trainees The Prevalence of Obstructive Sleep Apnea in Patients with Idiopathic Intracranial Hypertension Keywords: Prevalence, obstructive Sleep Apnea, Idiopathic Intracranial Hypertension Thymectomy in non-thymomatous MG patients receiving prednisone therapy Keywords: Neuromuscular Disorder, Thymectomy; prednisone, Myasthenia Gravis Ultrasound Aided Fixation of Biodegradable Implants in Pediatric Craniofacial Surgery Keywords: Craniosynostosis, craniofacial trauma, craniofacial fixation, craniofacial syndromes
For more information on these trials and other trials being conducted on this campus, please visit the UF Health Science Center Jacksonville Office for Research Affairs .
Health Encyclopedia
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Scott Silliman, M.D. - Stroke